Toxicology 21: Scientific Applications
Learn modern toxicology approaches for regulatory safety assessment. Explore high-throughput methods and alternatives to animal testing.
Learn modern toxicology approaches for regulatory safety assessment. Explore high-throughput methods and alternatives to animal testing.
This course introduces students to the novel concepts revolutionizing regulatory toxicology, based on the National Research Council Report "Toxicity Testing in the 21st Century: A Vision and a Strategy." It covers the shift from animal testing to human-relevant, high-content, high-throughput integrative testing strategies. The curriculum explores ToxCast and Tox21 technologies, adverse outcome pathways, the Human Toxome Project, and omics technologies. Students learn about read-across approaches, organotypic cultures, in vitro to in vivo extrapolation, and integrated testing strategies. The course also covers the role of miRNA and epigenetics in toxicology, as well as biometry perspectives on in vitro toxicology data analysis.
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What you'll learn
Understand the shift in toxicology from animal testing to human-relevant, high-throughput methods
Explore ToxCast and Tox21 technologies and their applications in regulatory toxicology
Learn about adverse outcome pathways (AOPs) and their role in predictive toxicology
Understand the Human Toxome Project and the use of omics technologies in toxicology
Explore read-across approaches and organotypic cultures for toxicity testing
Learn about in vitro to in vivo extrapolation and physiologically based biokinetic modeling
Skills you'll gain
This course includes:
121 Minutes PreRecorded video
9 assignments
Access on Mobile, Tablet, Desktop
FullTime access
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There are 7 modules in this course
This comprehensive course on 21st-century toxicology covers the latest developments in regulatory toxicology, focusing on the shift from animal testing to human-relevant, high-throughput testing strategies. It explores ToxCast and Tox21 technologies, adverse outcome pathways, the Human Toxome Project, and omics technologies. Students learn about read-across approaches, organotypic cultures, in vitro to in vivo extrapolation, and integrated testing strategies. The course also covers the role of miRNA and epigenetics in toxicology, as well as biometry perspectives on in vitro toxicology data analysis. It provides a thorough understanding of modern toxicology approaches for regulatory safety assessment and alternatives to animal testing.
Module 1
Module 1 · 74 Hours to complete
Module 2
Module 2 · 4 Hours to complete
Module 3
Module 3 · 2 Hours to complete
Module 4
Module 4 · 4 Hours to complete
Module 5
Module 5 · 1 Hours to complete
Module 6
Module 6 · 3 Hours to complete
Module 7
Module 7 · 3 Hours to complete
Fee Structure
Payment options
Financial Aid
Instructors
Doerenkamp-Zbinden Chair for Evidence-based Toxicology at Johns Hopkins University
Thomas Hartung is the Doerenkamp-Zbinden Chair for Evidence-based Toxicology with a joint appointment in Molecular Microbiology and Immunology at the Johns Hopkins Bloomberg School of Public Health. He also serves as a Professor of Pharmacology and Toxicology at the University of Konstanz, Germany. As the Director of the Centers for Alternatives to Animal Testing (CAAT) at both institutions, he leads initiatives aimed at advancing non-animal testing methods and promoting evidence-based toxicology. Hartung is known for his work on the Human Toxome project, which seeks to improve toxicity testing methodologies through innovative approaches, including organoid cultures and artificial intelligence. He previously headed the European Commission’s Center for the Validation of Alternative Methods (ECVAM) and has authored over 490 scientific publications, contributing significantly to the fields of toxicology and pharmacology. His research focuses on integrating big data and AI into predictive toxicology, aiming to enhance public health outcomes through improved testing strategies.
Research Associate at Johns Hopkins University
Lena Smirnova is a Research Associate at the Center for Alternatives to Animal Testing at the Johns Hopkins Bloomberg School of Public Health. Her research primarily focuses on developmental neurotoxicity and the role of microRNA in gene-environment interactions related to neurodevelopment and neurodegeneration. From 2007 to 2012, she worked as a Postdoctoral researcher at the Federal Institute of Risk Assessment in Berlin, Germany, where she coordinated a pre-validation study in inhalation toxicology while also researching neurotoxicology. Lena earned her PhD in Neuroscience from Charité – Universitätsmedizin Berlin in 2007, concentrating on microRNA's role in neural development and stem cell specification. She graduated from the International Sakharov Environmental University in Minsk, Belarus, in 2002, specializing in Radiobiology and Environmental Medicine. In addition to her research, Lena is involved in educational initiatives aimed at promoting modern toxicology methodologies.
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4.6 course rating
81 ratings
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